Author

Lexie E. Berkowicz

Stowers Institute for Medical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Randal HalfmanniD· 3 shared Alex T. Von SchulzeiD· 2 shared Danny D. SahtoeiD· 2 shared Georg MeisliD· 2 shared Hannah L. HaniD· 2 shared Shriram VenkatesaniD· 2 shared Tuomas P. J. KnowlesiD· 2 shared Alain GorielyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersBiophysics

Randal HalfmannORCID

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Author profile →

3 papers

Recent·Most cited

State-selective inhibition of alpha-synuclein aggregation by de novo oligomer-binding proteins

Yunxuan Zhang, Hannah L. Han, Lei Ortigosa-Pascual, Uri Z. Miles, Jiapeng Wei, Lexie E. Berkowicz, Finn Snow, Daizheng Tu, Georg Meisl, Shrutika Sansaria, Timothy J. Nott, Heike Laman, Randal Halfmann, Andrew C. McShan, Danny D. Sahtoe, Tuomas P. J. Knowles

This study designs de novo proteins that selectively inhibit alpha-synuclein aggregation by targeting specific intermediates, with one binder preferentially inhibiting oligomer formation and secondary nucleation.

bioRxiv · Sep 25, 2026 · PreprintBiophysics

Nascent protein retention at polysomes reduces kinetic barriers to self-assembly

Shriram Venkatesan, Alex T. Von Schulze, Jeffrey J. Lange, Jacob Jensen, Lexie E. Berkowicz, Dai Tsuchiya, Ning Zhang, Jennifer Gardner, Scott McCroskey, Ying Zhang, Selene K. Swanson, Yan Hao, Malcolm E. Cook, Tong Shu, Liam J. Holt, , Randal Halfmann

The paper shows that increasing translation initiation rates accelerates nucleation of aggregating proteins at polysomes, suggesting cotranslational nucleation influences proteome evolution.

bioRxiv · May 19, 2026 · PreprintCell Biology

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.

Matthew W. Cotton, Shriram Venkatesan, Joseph S. Beckwith, Dorothea Böken, Catherine K. Xu, Emre Fertan, Jonathan C. Breiter, Lexie E. Berkowicz, Laura Sancho Salazar, Alex T. Von Schulze, Ewa A. Andrzejewska, Emma E. Brock, Hannah L. Han, Matthias M. Schneider, Danny D. Sahtoe, , Georg Meisl

The paper identifies a cellular tipping point between aggregate accumulation and removal as a universal feature of neurodegeneration, validated through live-cell assays and super-resolution imaging.

bioRxiv · Sep 8, 2025 · PreprintNeuroscience