Author
The University of Texas MD Anderson Cancer CenterORCID 0000-0002-7706-7540Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Yusuke Nishimura, Adam J. Bittel, Abhishek Jagan, Yiwen Chen, Jatin G. Burniston
This study uses proteomics to show sex-specific differences in mitochondrial protein response to exercise in a mouse model of FSHD, highlighting potential sex-specific biomarkers.
Molecular & Cellular Proteomics · Jun 9, 2025Peer-reviewedPhysiology
Liang Zhang, Wei He, Rongjie Fu, Shuyue Wang, Yiwen Chen, Han Xu
The paper evaluates efficiency and off-target effects of high-fidelity Cas9 variants with different sgRNAs and develops a computational framework to predict their performance.
Nucleic Acids Research · Aug 14, 2023Peer-reviewedSystems Biology
Rongjie Fu, Wei He, Jinzhuang Dou, Oscar David Villarreal, Ella Bedford, Helen H. Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu
This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.
Nature Communications · Jan 25, 2022Peer-reviewedSystems Biology
Sapir Margalit, Yotam Abramson, Hila Sharim, Zohar Manber, Surajit Bhattacharya, Yiwen Chen, Eric J. N. Vilain, Hayk Barseghyan, Ran Elkon, Roded Sharan, Yuval Ebenstein
The paper develops a method to deconvolve cell-type mixtures using enhancer-promoter methylation profiles from long-read data, achieving higher accuracy than promoter-based approaches.
Bioinformatics · Apr 25, 2021Peer-reviewedBioinformatics
Wei He, Helen H. Wang, Yanjun Wei, Zhiyun Jiang, Yitao Tang, Yiwen Chen, Han Xu
GuidePro integrates multiple predictive methods to prioritize sgRNAs for CRISPR/Cas9 protein knockouts, showing consistent performance across datasets.
Bioinformatics · Dec 14, 2020Peer-reviewedBioinformatics