Author

Yalong Wang

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-9557-9101Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Han XuiD· 3 shared Rongjie Fu· 3 shared Wei HeiD· 3 shared Ella Bedford· 2 shared Mark T. BedfordiD· 2 shared Shuyue WangiD· 2 shared Alberto CicciaiD· 1 shared Alina VaitsiankovaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

Han XuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Acquired resistance to the PRMT5 inhibitor confers collateral sensitivity to MEK inhibition in MTAP-null non-small cell lung cancer

Rongjie Fu, Yalong Wang, Ishita Rehman, Ella Bedford, Sana Sharif, Nghi D. Nguyen, Reid Trenton Powell, Andrew Adams, W LIU, Shuyue Wang, Wei He, Yue Lu, Bin Liu, Pooja Anil Shah, Jordi Ahnert Rodon, , Han Xu

The paper identifies collateral sensitivity to MEK inhibition in MTAP-null NSCLC cells that develop resistance to PRMT5 inhibitors.

Biomolecules · Aug 17, 2026Peer-reviewedCancer Biology

Mechanistic Insights into Proteomic Mutation-Phenotype Linkages from Tiling Mutagenesis Screens

Wei He, Jen‐Wei Huang, Yalong Wang, Samuel B. Hayward, Giuseppe Leuzzi, Rongjie Fu, Shuyue Wang, Alina Vaitsiankova, Mark T. Bedford, Raphaël Guérois, Alberto Ciccia, Han Xu

The paper introduces ProTiler-Mut, a framework for analyzing tiling mutagenesis screens to uncover mutation-phenotype linkages, revealing new insights into functional mutation categories and protein interactions.

bioRxiv · Apr 17, 2025 · PreprintBioinformatics

Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

Rongjie Fu, Wei He, Jinzhuang Dou, Oscar David Villarreal, Ella Bedford, Helen H. Wang, Connie Hou, Liang Zhang, Yalong Wang, Dacheng Ma, Yiwen Chen, Xue Gao, Martin Depken, Han Xu

This study systematically identifies sequence determinants of CRISPR/Cas9 specificity by analyzing off-target effects of 1,902 gRNAs on 13,314 targets, revealing three key factors and developing a predictive tool.

Nature Communications · Jan 25, 2022Peer-reviewedSystems Biology