Toni‐Kim Clarke

The paper examines DNA methylation patterns in smokers and former smokers to determine how exposure duration and dose affect methylation changes and their reversal after cessation.

This paper performs a genome-wide association study meta-analysis of AUDIT scores in two cohorts, identifying risk loci and genetic correlations with alcohol consumption and psychiatric disorders.

The paper applies polygenic risk scoring to a large family with bipolar and depressive disorders to study genetic risk patterns and anticipation.

This study identifies 114 genome-wide significant loci for schizophrenia and bipolar disorder, with specific subphenotype associations and four genes distinguishing the disorders.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

The paper addresses concerns about a negative genetic correlation between BMI and alcohol consumption in a GWAS, arguing that the correlation arises from the statistical model used.

This study examines the association between polygenic risk scores for Major Depressive Disorder derived from the NETRIN1 pathway and whole-genome variants with white matter microstructure in the UK Biobank.

The paper investigates the genetic and environmental contributions to stressful life events and their overlap with depression and neuroticism using a large family-based sample.

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.

The paper identifies 116 independent genetic variants associated with neuroticism in over 329,000 UK Biobank participants and finds genetic correlations with mental health traits.

This study performs a genome-wide haplotype-based association analysis for major depressive disorder using two cohorts, identifying significant haplotypes potentially linked to the disorder.

This study finds accelerated epigenetic ageing in major depressive disorder (MDD) cases compared to controls using the Horvath clock, partially mediated through BMI.

This study investigates shared genetic architecture between subcortical brain volumes and MDD using GWAS data from multiple cohorts, finding a non-significant positive genetic correlation for hippocampal volume.

This study conducts a GWAS of alcohol consumption in UK Biobank, identifying 8 loci, including novel associations, and reports genetic overlaps with schizophrenia, HDL cholesterol, smoking, and anthropometric traits.

This study investigates the interaction between polygenic risk scores for schizophrenia and major depressive disorder (MDD) in two cohorts, finding reduced case-control differences in distress and neuroticism with higher schizophrenia risk.

This study identifies genetic and environmental factors contributing to chronic pain and its link to major depressive disorder using data from Generation Scotland and UK Biobank.