Matthias Mack

This study identifies riboflavin as a modulator of ferroptosis sensitivity by supporting FSP1 stability and antioxidant recycling, with implications for therapeutic targeting.

The paper identifies dual targeting of riboflavin metabolism and MEK as a novel therapeutic strategy for pancreatic cancer by showing synergistic suppression of PDAC xenograft growth.

This study identifies a mutation in the P. falciparum flavokinase gene that confers resistance to roseoflavin and 8-aminoriboflavin by reducing substrate binding affinity.

This paper designs synthetic small RNAs to target bacterial riboswitches, enhancing gene expression up to 103-fold and improving riboflavin production in engineered strains.