Author

Ritam Sinha

Michigan State UniversityORCID 0000-0002-7809-5324Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Elizabeth N. OttoseniD· 3 shared Victor J. DiRitaiD· 3 shared Aric N. BrowniD· 1 shared Barsha Bhattarai· 1 shared Bridget S. MoricziD· 1 shared Caitlyn L. HolmesiD· 1 shared Cristina Kraemer ZimpeliD· 1 shared Derrick E. FoutsiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMicrobiology

Elizabeth N. OttosenORCID

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3 papers

Recent·Most cited

Microbiota-derived indole limits Campylobacter jejuni colonization by inhibiting respiration and metabolism

Ritam Sinha, Barsha Bhattarai, Cristina Kraemer Zimpel, Elizabeth N. Ottosen, Rhiannon M. LeVeque, Pallavi Singh, Victor J. DiRita

This study shows that microbiota-derived indole inhibits Campylobacter jejuni colonization by disrupting its respiration and metabolism in an inflamed gut.

Science Advances · Sep 16, 2026Peer-reviewedMicrobiology

Carbapenem-Resistant Enterobacter hormaechei Uses Mucus Metabolism to Facilitate Gastrointestinal Colonization

Ritam Sinha, Elizabeth N. Ottosen, Tshegofatso Ngwaga, Stephanie R. Shames, Victor J. DiRita

This study develops a neonatal mouse model to investigate gut colonization by carbapenem-resistant Enterobacter hormaechei, revealing mucus metabolism as a key factor in intestinal colonization.

mBio · Jan 29, 2025Peer-reviewedMicrobiology

A novel method for integrating genomic and Tn-Seq data to identify common in vivo fitness mechanisms across multiple bacterial species

Derrick E. Fouts, Thomas H. Clarke, Aric N. Brown, Elizabeth N. Ottosen, Caitlyn L. Holmes, Bridget S. Moricz, Sophia Mason, Ritam Sinha, Geoffrey B. Severin, Mark T. Anderson, Victor J. DiRita, Michael A. Bachman, Harry L. T. Mobley

The paper integrates Tn-Seq fitness data with functional data to identify seven common fitness mechanisms across five Enterobacterales species, validating one gene's role in bacteremia and antibiotic resistance.

bioRxiv · Jul 24, 2024 · PreprintBioinformatics