Thomas R. Mumford

Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

Low-order assemblies drive oncogenic RTK fusion signaling without condensation

This study shows that low-order RTK fusions can drive oncogenic signaling without forming condensates, challenging the role of condensation in signal transmission.

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains.

This study shows nuclear-import receptors suppress RNA-binding protein phase transitions by remodeling the dilute phase, preventing disease-linked aggregation.

A temperature-inducible protein module for control of mammalian cell fate

This paper introduces a temperature-inducible protein module called Melt that allows reversible control of mammalian cell processes through temperature changes, demonstrating its utility in cell death control in a mouse cancer model.

Multiplexed dynamic control of temperature to probe and observe mammalian cells.

The paper introduces thermoPlate, a device for dynamic temperature control in cell culture, and uses it to study temperature-dependent cellular responses like phase separation and stress granule dynamics.