Lu Huang

The paper uses single-cell RNA sequencing and flow cytometry to analyze myeloid cells in young and aged mouse ovaries, identifying aging-related changes in macrophage subsets and signaling pathways.

This study identifies MRC1 as a key receptor for dextran uptake in macrophages via receptor-mediated endocytosis, distinguishing it from fluid-phase uptake mechanisms.

The paper shows that intraperitoneal administration of β-glucan and IFNγ clears ascites and induces IL27-dependent tumor regression in metastatic ovarian cancer models.

The paper uses network modeling to identify molecular mechanisms driving T cell exhaustion and validates predictions through experimental testing.