Author

Akash Kumar Jha

Indian Institute of Technology BombayORCID 0000-0002-4580-1480Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Ashutosh KumariD· 2 shared Gautam Kannan· 2 shared Md Asrafuddoza HazariiD· 2 shared Shamik SeniD· 2 shared Debanjana DasiD· 1 shared Farhin SultanaiD· 1 shared Hamim ZafariD· 1 shared Musale Krushna PavaniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Ashutosh KumarORCID

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3 papers

Recent·Most cited

Lipid Droplets Direct Amyloid Assembly and β-Cell Stress through Interfacial Control of Amylin Aggregation

Akash Kumar Jha, Md Asrafuddoza Hazari, Sneha Singh, Gautam Kannan, Shamik Sen, Ashutosh Kumar

This study shows lipid droplets modulate amylin aggregation and β-cell stress by controlling its conformational changes and interaction pathways.

bioRxiv · Jun 16, 2026 · PreprintCell Biology

Electrostatics Govern Protein Orientation on Citrate-Capped Gold Nanoparticles

Suman Tiwari, Akash Kumar Jha, Simran Arora, Debanjana Das, Sri Rama Koti Ainavarapu

The paper investigates how electrostatic interactions influence protein-GNP conjugation by mutating lysine to cysteine in protein L and showing that nearby positive charges enhance capping.

bioRxiv · Nov 7, 2025 · PreprintBiophysics

Faster amylin aggregation on fibrillar collagen hastens diabetic progression through β cell death and loss of function

Md Asrafuddoza Hazari, Gautam Kannan, Subrata Dasgupta, Musale Krushna Pavan, Akash Kumar Jha, Farhin Sultana, Soumya Ranjan Pujahari, Simran Singh, Sarbajeet Dutta, Sai Prasad Pydi, Sankhadeep Dutta, Hamim Zafar, Prasenjit Bhaumik, Ashutosh Kumar, Shamik Sen

This study shows that amylin aggregates faster on fibrillar collagen, leading to β-cell death and dysfunction, which accelerates diabetic progression.

Journal of the American Chemical Society · Apr 29, 2025Peer-reviewedBiophysics