Michael A. Silverman

Brain-Resident CD8+ T Cells Regulate Neuronal Activity and Behavior via Interferon-Gamma

This study identifies brain-resident CD8+ T cells that regulate neuronal activity and behavior through interferon-gamma secretion, showing their role in maintaining brain homeostasis.

Microbial succession at weaning is guided by microbial metabolism of host glycans.

This study shows that microbial succession during weaning is driven by the ability of microbes to metabolize host glycans, using a mouse model and genomic analysis.

Single-cell quantification of the microbiota by flow cytometry: MicFLY

The paper develops MicFLY, a flow cytometry method to quantify and characterize intestinal microbiota at the single-cell level, revealing E. coli unbound by IgG and IgA is associated with necrotizing enterocolitis.

Comparison of gnotobiotic communities reveals unexpected amino acid metabolism by the pre-weaning microbiome.

The paper compares gnotobiotic microbiomes to identify unique amino acid metabolism in the pre-weaning microbiome.

Early-life exposures to specific commensal microbes prevent type 1 diabetes.

A defined consortium of early-life microbes shapes immune development and prevents type 1 diabetes.