Mingsheng Li

Structural and compositional profiling of individual biomolecular assemblies by infrared absorbance-modulated evanescent scattering

This paper introduces IR-AMES, a technique for ultrasensitive structural and compositional analysis of individual biomolecular assemblies in aqueous environments, revealing insights into tau oligomers and their interactions with membranes.

Blood-Mediated Opto-Acoustic Stimulation of Brain Cortex at Sub-millimeter Precision

This paper introduces blood-mediated optoacoustic stimulation (BOAS) for precise brain cortex stimulation, showing it can trigger neuronal activity comparable to natural visual stimulation and is more efficient than photothermal methods.

Mid-Infrared Photothermal Imaging Unveils Altered Stearoyl-CoA desaturase (SCD) Activity in Ovarian Cancer Cells

This study uses mid-infrared photothermal imaging to measure SCD activity in ovarian cancer cells and finds altered activity in treated cells and cancer stem cells.

Ultrasensitive in vivo infrared spectroscopic imaging via oblique photothermal microscopy

This paper introduces an oblique photothermal microscope (OPTM) for ultrasensitive in vivo IR spectroscopic imaging with sub-micron resolution, enabling low-dose imaging of skin and tracking of topical drugs.

Click-free imaging of carbohydrate trafficking in live cells using an azido photothermal probe

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.