Philipp Walch

This study uses CRISPRi to identify pneumococcal genes critical for attachment and survival during single infection and influenza co-infection, revealing key metabolic and structural dependencies.

This study uses T-DARPins to inhibit TBXT in chordoma cells, revealing its regulome and identifying therapeutic vulnerabilities, including sensitivity to JAK2 inhibitors.

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.