Author

M. S. J. Mangan

University of BonnORCID 0000-0001-5990-3034Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

M. S. J. Mangan1 paper

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Assay:metabolomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Eicke LatziD· 3 shared Fraser Duthie· 3 shared Agnes SchröderiD· 2 shared Anil AkbaliD· 2 shared Dagmar WachteniD· 2 shared Felix MeissneriD· 2 shared Jonathan JantschiD· 2 shared Kshiti Meera Phulphagar· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersImmunology

Eicke LatzORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintFeb 25, 2026

NLRP3 activators disrupt the endocytic AP2 complex and plasma membrane signaling

Stefan Ebner, Kshiti Meera Phulphagar, Yubell Alvarez…·Felix Meissner

The paper shows NLRP3 activators disrupt the AP2 complex and impair plasma membrane signaling, leading to inflammation and cell death.

DOI 10.64898/2026.02.24.707400

humanproteomics

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ImmunologyCell ReportsPeer-reviewedSep 1, 2024

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation

Wei Wang, Alesja Dernst, Bianca Martin…·M. S. J. Mangan

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

135 citationstop 1%

humanproteomics

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ImmunologybioRxivPreprintMar 26, 2024

Cytosolic sodium accumulation is a common danger signal triggering endocytic dysfunction and NLRP3 inflammasome activation

M. S. J. Mangan, Anil Akbal, Sophie Rivara…·Eicke Latz

The paper shows that cytosolic sodium accumulation triggers NLRP3 inflammasome activation in response to various danger signals in human macrophages.

3 citations

humanproteomics

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