Shaheen S. Sikandar

This study identifies BCL11B as a determinant of chemoresistance in breast cancer, showing it promotes a persister state that TNFα can reverse.

This study shows that LMO2 maintains a hybrid epithelial-mesenchymal state in mammary epithelial cells and its loss promotes mesenchymal differentiation and reduces organoid formation.

This study shows U2AF1S34F enhances lung cell tumorigenicity when combined with KRAS mutations and environmental stress, altering splicing and stress responses.

This study shows pregnancy reduces Il33+ hybrid progenitor cells in aged mammary glands, improving lineage integrity and potentially lowering breast cancer risk.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

This study uses single-cell RNA-sequencing to analyze cell type-specific responses to young or aged blood in heterochronic parabiosis, identifying mitochondrial function as a key factor in rejuvenation.

The paper introduces CytoTRACE, a method using transcriptional diversity to predict differentiation states from scRNA-seq data, outperforming existing methods and identifying stem cells and tumor-related genes.

This study identifies CDK19 as a therapeutic target for TNBC by showing its role in tumor growth and metastasis, with minimal impact on normal cells.