Tobias U. Hauser

Inhibitory control and error processing in Obsessive-Compulsive Disorder: A mega-analysis of task-based fMRI data by the ENIGMA-OCD consortium

This study analyzes fMRI data from OCD patients and controls to identify age-specific differences in brain activation during inhibitory control and error processing.

Dorsomedial prefrontal cortex acts as an integrative hub during information gathering

The paper identifies a neural mechanism in the dorsomedial prefrontal cortex involved in information gathering during decision-making, linking it to cognitive processes like urgency and evidence accumulation.

Cortical Microstructural Variations Correlate with Individual Differences in Gamified Exploration-Exploitation Behaviours

This study links cortical microstructural features to individual differences in exploration-exploitation decision-making strategies using a gamified task and quantitative MRI.

Frontotemporal cortex flexibly adapts latent structural representations

The paper investigates how the human brain dynamically reconfigures internal models of environmental structure in response to changes, identifying distinct neural patterns in specific brain regions.

Dissociable Microstructural Correlates of Learning Rate and Learning Noise in Gamified Reward-Based Decision-Making

This study identifies distinct microstructural brain correlates of learning rate and learning noise in reward-based decision-making using computational modeling and quantitative MRI.

Indecision and recency-weighted evidence integration in non-clinical and clinical settings

The paper identifies a bias in information weighting, specifically reduced recency-weighted evidence integration, as a driver of indecisiveness across obsessive-compulsive and anxiety disorders.

Dopamine drives a positive reward bias on human reinforcement learning

This study investigates how dopamine affects reinforcement learning in humans using L-DOPA and finds it reduces switching after low rewards and influences learning rate and precision.

Peripheral Beta-Blockade Differentially Enhances Cardiac and Respiratory Interoception

This study investigates how beta-blockers affect cardiac and respiratory interoception using computational modeling, finding differential impacts on perceptual sensitivity and metacognition.

Biased replay of aversive and uncertain outcomes underlies irrational decision making

The paper shows that biased neural replay of aversive and uncertain outcomes underlies irrational decision making in humans.

Human adolescent brain similarity development is different for paralimbic versus neocortical zones

The paper examines how morphometric similarity in brain regions changes during adolescence, finding distinct developmental patterns in paralimbic versus neocortical areas.

Boosting serotonin increases information gathering by reducing subjective cognitive costs

The paper shows that boosting serotonin reduces sensitivity to cognitive effort during information gathering, increasing willingness to gather information for reward.

Early life adversities affect expected value signaling in the adult brain

The paper investigates how early life adversities impact reward learning and decision-making in adults using neurocomputational methods and fMRI data from a longitudinal cohort.

Uncertain Precision: Neurobiological and Physiological Correlates of Conservative Confidence Bias

The paper investigates how sensory precision affects confidence in decision-making, finding systematic under-confidence in low-precision stimuli and linking it to neural and physiological factors.

Children are full of optimism, but those rose-tinted glasses are fading: reduced learning from negative outcomes drives hyperoptimism in children.

The paper shows children exhibit greater optimism bias than adolescents, driven by reduced learning from negative outcomes.

Reliability of web-based affective auditory stimulus presentation

This study evaluates the reliability of affective auditory stimuli presented online, finding good test-retest reliability and internal consistency comparable to in-lab settings.

An expanding manifold of transmodal regions characterizes adolescent reconfigurations of structural connectome organization

The paper uses manifold learning to analyze longitudinal structural connectome data, showing expansion in transmodal regions during adolescence and linking it to cognitive outcomes.

White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

This study identifies white matter microstructural alterations in adult OCD patients and links them to clinical features, while finding no such abnormalities in pediatric patients.

Tabula-rasa exploration decreases during youth and is linked to ADHD symptoms

The paper shows that children and younger adolescents use more computationally light exploration strategies, which is linked to ADHD traits, and this decreases with age.

Childhood socio-economic disadvantage predicts reduced myelin growth across adolescence and young adulthood

This study shows childhood socio-economic disadvantage is linked to reduced myelin growth in adolescence and young adulthood, with some protective effects from parental education and positive parenting.

Human complex exploration strategies are extended via noradrenaline-modulated heuristics

The paper shows humans use computationally cheap exploration strategies, with value-free random exploration controlled by noradrenaline.

Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia risk genes

The paper links schizotypy-related magnetization in adolescent cortex to schizophrenia risk genes using MRI and gene expression data.

Brain-behaviour modes of covariation in healthy and clinically depressed young people

The paper identifies two modes of brain-behavior covariation in adolescents and young adults using canonical correlation analysis, linking brain connectivity to psychometric, IQ, and demographic data.

The value of what’s to come: neural mechanisms coupling prediction error and reward anticipation

The paper investigates how neural systems compute anticipatory value from future rewards, showing three brain regions coordinate this process.

Compulsivity and impulsivity are linked to distinct aberrant developmental trajectories of fronto-striatal myelination

The paper links compulsivity and impulsivity to distinct patterns of fronto-striatal myelination during adolescence using longitudinal MRI data.

Computational mechanisms of curiosity and goal-directed exploration

The paper presents two computational mechanisms for goal-directed exploration based on different types of information-gain, showing how they induce distinct patterns of Bayes-optimal behavior.

Fractionation of impulsive and compulsive trans-diagnostic phenotypes and their longitudinal associations

This study identifies a bi-factor model to fractionate impulsive and compulsive problem behaviors in young adults and finds distinct antecedents for each phenotype.

Noradrenaline modulates decision urgency during sequential information gathering

This study investigates how noradrenaline and dopamine affect information gathering during decision-making, finding that noradrenaline blockade reduces information gathering through increased decision urgency.

Metacognitive impairments extend perceptual decision making weaknesses in compulsivity

This study shows that compulsivity is linked to reduced metacognitive ability and slower perceptual decision making.