Gianfranco Spalletta

Sex differences in deep brain shape and asymmetry persist across schizophrenia and healthy individuals: A meta-analysis from the ENIGMA-Schizophrenia Working Group

Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and Size

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study

This study investigates how structural brain alterations in schizophrenia relate to network architecture, finding hub susceptibility and shared epicenters across disease stages and disorders.

Estimating multimodal brain variability in schizophrenia spectrum disorders: A worldwide ENIGMA study

This study examines structural brain heterogeneity in schizophrenia using multimodal MRI data from the ENIGMA dataset, finding higher frontotemporal heterogeneity and left parahippocampal homogeneity in patients.

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimers Disease

The paper identifies rare damaging variants in ATP8B4 and ABCA1 as novel risk factors for Alzheimer's Disease using exome sequencing data from 32,558 individuals.

Chronic stroke sensorimotor impairment is related to smaller hippocampal volumes: An ENIGMA analysis

This study finds that smaller ipsilesional hippocampal volume is associated with worse upper limb sensorimotor impairment in chronic stroke patients, with a stronger effect in women.

Global brain health modulates the impact of lesion damage on post-stroke sensorimotor outcomes

This study shows that global brain health, measured by brain age, influences post-stroke sensorimotor outcomes and mediates the effect of lesion damage.

Smaller spared subcortical nuclei are associated with worse post-stroke sensorimotor outcomes in 28 cohorts worldwide

This study finds that smaller spared subcortical nuclei are linked to worse sensorimotor outcomes after stroke, varying by time since stroke and type of impairment.

White Matter Microstructure and its Relation to Clinical Features of Obsessive-Compulsive Disorder: Findings from the ENIGMA OCD Working Group

This study identifies white matter microstructural alterations in adult OCD patients and links them to clinical features, while finding no such abnormalities in pediatric patients.

Gene-Based Analysis in HRC Imputed Genome Wide Association Data Identifies Three Novel Genes For Alzheimer’s Disease

The paper uses a novel gene-based analysis approach to identify three novel genes associated with Alzheimer’s disease using genome-wide association data.

Deep Learning for Quality Control of Subcortical Brain 3D Shape Models

The paper develops deep learning models to assess the quality of subcortical brain shape models from MRI, reducing human rater time by 46-70%.

Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging

This work uses machine learning to automate quality control of 3D brain shape models, reducing human workload by 30-70% across multiple datasets and diseases.