Kazuhide S. Okuda

Target RNA abundance controls the collateral activity of RfxCas13d in human cells and zebrafish embryos

This study shows that target RNA abundance controls collateral activity of RfxCas13d in human cells and zebrafish embryos, with high abundance causing widespread degradation and toxicity.

Single cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

This study uses single-cell transcriptomics to investigate Prox1's role in lymphatic endothelial cell fate specification and differentiation in zebrafish, identifying new transcriptional targets and regulatory mechanisms.

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

This study uses a zebrafish Erk biosensor to live-image dynamic Erk-signalling events during regenerative angiogenesis, revealing sequential Ca2+- and Vegfr-dependent mechanisms.