Integrin β1-Talin1 at focal adhesions underpin uncontrolled endothelial cell enlargement in live cerebral cavernous malformation vasculature
Mikaela S. Keyser, Teodor E. Yordanov, Jason A. da Silva, Tevin Chui-Ying Chau, Elysse K. Morris, Scott Paterson, Neil Ivan Bower, Katarzyna Koltowska, Gregory J. Baillie, Cas Simons, Robert G. Parton, Kelly Smith, Benjamin M. Hogan, Anne K. Lagendijk
This study shows integrin β1-Talin1 at focal adhesions drive uncontrolled endothelial cell enlargement in CCM vasculature, independent of KLF2/4.
bioRxiv · Nov 25, 2025 · PreprintCell Biology