Yi‐Chen Hsieh

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

The paper analyzes transcriptome and proteome changes in a Drosophila tauopathy model, identifying age- and Tau-induced gene expression differences and their cross-species implications.

This study shows that Tau disrupts the spliceosome, leading to cryptic RNA splicing and neurodegeneration in Alzheimer’s disease.