Julie Le Merrer

Tilted striatofugal balance and beneficial effects of facilitating mGlu4 receptor activity in the Fmr1-/- mouse model of Fragile X Syndrome

The paper investigates D1/D2-SPN balance in FXS mice and shows that mGlu4 facilitation rescues social deficits.

Neurobiological alterations and autism-like phenotype in mice following regulatory-limit exposure to fungicides in drinking water

This study shows that low-dose exposure to a fungicide mixture in drinking water impairs brain development and induces autism-like behaviors in mouse offspring.

Acute, chronic and conditioned effects of intranasal oxytocin in the mu opioid receptor knockout mouse model of autism: social context matters

This study examines the effects of intranasal oxytocin in Oprm1 knockout mice, finding dose- and context-dependent improvements in social behavior and gene expression changes.

Balance between direct and indirect pathways of the nucleus accumbens controls social behavior in mice

This study investigates the role of D1R- and D2R-SPNs in the nucleus accumbens in modulating social behavior and related neuropsychiatric traits in mice.

Chronic sodium bromide treatment relieves autistic-like behavioral deficits in three mouse models of autism

This study shows that chronic sodium bromide treatment reduces autistic-like behaviors in three mouse models of autism, with synergistic effects when combined with an mGlu4 receptor modulator.

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

This study shows that p-Cresol, a microbial metabolite more abundant in ASD patients, induces ASD-like behaviors in mice through gut microbiota-dependent mechanisms.

Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure

This study shows that chronic administration of the mGluR4 PAM VU0155041 reverses long-term behavioral deficits in morphine-abstinent mice by restoring gene expression in the nucleus accumbens.