Author

Amanda A. Bedwell

Indiana University Indianapolis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kierra Eldridge· 3 shared Paul R. TerritoiD· 3 shared Scott A. PersohniD· 3 shared Alaina M. ReaganiD· 2 shared Gareth R. HowelliD· 2 shared Lucas L. FigueiredoiD· 2 shared Michael SasneriD· 2 shared Rachael Speedy· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Kierra Eldridge

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease

Amandine Jullienne, Jenny I. Szu, Ryan Quan, Michelle V. Trinh, Tannoz Norouzi, Brenda P Noarbe, Amanda A. Bedwell, Kierra Eldridge, Scott A. Persohn, Paul R. Territo, André Obenaus

This study examines vascular and metabolic changes in 5xFAD mice over time, finding sex-specific differences in vascular features and glucose metabolism linked to Alzheimer's pathology.

Frontiers in Aging Neuroscience · Jul 18, 2023Peer-reviewedNeuroscience

The 677C>T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice

Alaina M. Reagan, Karen E. Christensen, Leah C. Graham, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Lucas L. Figueiredo, Scott A. Persohn, Teodoro Bottiglieri, Kwangsik T. Nho, Michael Sasner, Paul R. Territo, Rima R. Rozen, Gareth R. Howell

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.

Journal of Cerebral Blood Flow & Metabolism · Sep 1, 2022Peer-reviewedGenetics

Plcg2M28L interacts with high fat-high sugar diet to accelerate Alzheimers disease-relevant phenotypes in mice

Adrian L. Oblak, Kevin P. Kotredes, Ravi S. Pandey, Alaina M. Reagan, Cynthia M. Ingraham, Bridget M Perkins, Christopher Lloyd, Deborah Baker, Peter Bor‐Chian Lin, Disha M. Soni, Andy Po‐Yi Tsai, Scott A. Persohn, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, , Gareth R. Howell

This study shows that a high fat-high sugar diet interacts with the Plcg2M28L genetic variant to accelerate Alzheimer's disease-like phenotypes in mice.

Frontiers in Aging Neuroscience · Jun 24, 2022Peer-reviewedNeuroscience