Author

Minna Mutka

University of HelsinkiORCID 0000-0002-8380-7293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel NicoriciiD· 3 shared Johanna MattsoniD· 3 shared Juha T. KlefströmiD· 3 shared Laura NiinikoskiiD· 3 shared Panu E. KovaneniD· 3 shared Tuomo J MeretojaiD· 3 shared Aino PeuraiD· 2 shared Andrei GogaiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Daniel NicoriciORCID

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3 papers

Recent·Most cited

Microtubule Inhibition Triggers MYC-Mediated Immunogenic Cell Death in Breast Cancer

Ruixian Liu, July Aung, Aino Peura, Antti O. Hiltunen, Linda Id, Mariel Savelius, Martina Peltonen, Rita Turpin, Natasha Salmelin, Johanna M. Anttila, Topi Aulis Tervonen, Ilida Suleymanova, Daniel Nicorici, Minna Mutka, Johanna Mattson, , Juha T. Klefström

The paper identifies microtubule inhibitors as inducers of immunogenic cell death in MYChigh TNBC, linking MYC-dependent DAMP release to immune activation and tumor protection.

bioRxiv · Aug 26, 2025 · PreprintCancer Biology

Complex I Drives Glutamine-Dependent TCA Cycle to Support Viability of MYChigh Breast Cancer Cells

Johanna M. Anttila, Mariel Savelius, Juhi Somani, Daniel Nicorici, Pauliina Munne, Linda Id, Aino Peura, Antti O. Hiltunen, July Aung, Ryan Awadhpersad, Bina Prajapati, Martina Peltonen, Hanna Ala-Hongisto, Prson Gautam, Mika J. Välimäki, , Juha T. Klefström

This study identifies enhanced mitochondrial respiration and glutamine-dependent TCA cycle as vulnerabilities in MYChigh breast cancer cells, showing synthetic lethality with complex I inhibitors.

bioRxiv · May 27, 2025 · PreprintCancer Biology

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

Rita Turpin, Karita Peltonen, Jenna H. Rannikko, Ruixian Liu, Anita N. Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo J Meretoja, Johanna Mattson, Petrus Järvinen, Kanerva Lahdensuo, Riikka Järvinen, , Juha T. Klefström

The paper evaluates immunomodulatory drug responses in patient-derived tumor explant models of breast and renal cancer, finding reproducible gene expression and cytokine changes across models.

OncoImmunology · Feb 17, 2025Peer-reviewedImmunology