Author

Perwez Alam

University of CincinnatiORCID 0000-0002-7229-8008Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Michelle L. NiemaniD· 3 shared Onur KanisicakiD· 3 shared John N. LorenziD· 2 shared Michael TranteriD· 2 shared Akhil BabyiD· 1 shared Albert Phillip OwensiD· 1 shared Aleksandra BinekiD· 1 shared Brent Cernyar· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

Michelle L. NiemanORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure

James W. McNamara, Taejeong Song, Perwez Alam, Akhil Baby, Aleksandra Binek, Kalyani Ananthamohan, Rohit R. Singh, Michelle L. Nieman, Marloes van den Berg, Brent Cernyar, Sheryl E. Koch, Malina J. Ivey, Thomas L. Lynch, James T. Pearson, Jack Rubinstein, , Sakthivel Sadayappan

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

Basic Research in Cardiology · Aug 5, 2026Peer-reviewedPhysiology

MCM2 mediates post-MI cardioprotection by promoting the pro-angiogenic cardiosome signaling

Perwez Alam, Wei Chieh Huang, Mike Adam, Michelle L. Nieman, Spencer Stutenroth, Michael Tranter, Yigang Wang, Onur Kanisicak

This study shows that re-expressing MCM2 in adult cardiomyocytes promotes the secretion of pro-angiogenic cardiosomes, improving cardiac function and reducing fibrosis after myocardial infarction.

bioRxiv · Dec 12, 2024 · PreprintPhysiology

HuR inhibition reduces post-ischemic cardiac remodeling by dampening acute inflammatory gene expression and the innate immune response

Samuel Slone, Sarah Anthony, Lisa C. Green, Michelle L. Nieman, Perwez Alam, Xiaoqing Wu, Sudeshna Roy, Jeffrey Aubé, Liang Xu, John N. Lorenz, Albert Phillip Owens, Onur Kanisicak, Michael Tranter

This study shows that inhibiting HuR reduces cardiac remodeling after ischemia-reperfusion injury by dampening inflammatory gene expression and immune response, but not initial infarct size.

bioRxiv · Jan 17, 2023 · PreprintMolecular Biology