Mike Adam

This study uses single-cell and spatial omics to identify plasticity and therapeutic targets in metastatic high-risk neuroblastoma.

The paper functionally characterizes DDX41 variants, showing some non-truncating germline variants are susceptible to dominant-negative effects by the somatic hotspot mutation p.R525H.

The paper identifies thin descending limb cells in developing mouse kidneys using scRNA-seq and shows they originate from proximal tubule cells, with Hnf4a playing a role in their development.

The paper identifies injury-induced cell states associated with regeneration in spiny mice, contrasting with fibrotic healing in mice, by analyzing proliferation dynamics and cell type-specific gene expression.

The paper shows that inter-species mRNA transfer from mouse embryonic stem cells to human pluripotent stem cells reprograms them to a naive-like state through specific transcription factors.

This study shows that re-expressing MCM2 in adult cardiomyocytes promotes the secretion of pro-angiogenic cardiosomes, improving cardiac function and reducing fibrosis after myocardial infarction.

The paper identifies Gucy1α1 as a specific marker for fibroblasts in multiple organs, showing its expression increases in fibrotic conditions across mouse and human tissues.

This study shows that interstitial Notch signaling regulates proximal tubule development in mouse kidneys through the Gata3-Renin axis.

This study uses single-cell RNA sequencing to identify novel transcriptional signatures and epithelial-stromal interactions in acute kidney injury.

The paper identifies shared and species-specific enteric neuron subtypes in humans and mice using transcriptional profiling and in situ visualization.

The paper shows that Gsx2 and Ascl1 physically interact in the mouse lateral ganglionic eminence, inhibiting Ascl1-driven neurogenesis and promoting progenitor expansion.

This study uses single cell RNA-seq to analyze the developing mouse uterus, identifying cell types and gene expression changes in Hox9,10,11 mutants.