Premal Shah

This study identifies and characterizes stress-induced small proteins in E. coli, showing YoaI mediates cross-talk between signaling systems during Mg2+ starvation.

The paper quantifies natural selection and mutation biases on a per-codon basis across budding yeast species, showing how changes in the tRNA pool influence codon usage bias and macroevolutionary variation.

This study shows human antimicrobial peptides like LL-37 activate bacterial PhoQ-PhoP signaling independently of their bactericidal effects, revealing a new mechanism of bacterial response to host peptides.

The paper estimates single-cell protein decay rates of degron GFPs in yeast and finds substantial cell-to-cell variability in decay rates, suggesting the need for complex decay dynamics models in gene expression noise estimation.

riboviz 2 provides a flexible and robust workflow for analyzing and visualizing Ribo-seq data with improved functionality and usability.

The paper shows HIF-1 promotes gluconeogenesis by upregulating PCK-1 in C. elegans, revealing a new role for HIF-1 beyond glycolysis.

This study shows that mice lacking the gastrin-releasing peptide gene exhibit enhanced fear conditioning and impaired extinction, with reduced dopamine-related gene transcription in the basolateral amygdala during stress-enhanced fear learning.

This study shows RPLP1 and RPLP2 enhance ribosome elongation and protein stability for flaviviral and cellular multi-pass transmembrane proteins by relieving ribosome pausing.

The paper shows tRNA U34-thiolation regulates phosphate homeostasis, linking carbon and nitrogen metabolism to cell cycle progression by controlling metabolic flux and phosphate availability.

This study shows IMP1 regulates intestinal epithelial repair after irradiation and colitis by modulating autophagy through direct binding to autophagy transcripts.

The paper introduces riboviz, a tool for analyzing and visualizing ribosome profiling datasets, providing both a backend pipeline and a web-based interface for comparison with public datasets.