Robert O. Heuckeroth

Enteric nervous system degeneration in human and murine CLN3 disease, is ameliorated by gene therapy in mice

This paper shows that CLN3 disease causes enteric nervous system degeneration in humans and mice, which can be prevented by neonatal gene therapy in mice.

Rapid cyclic stretching induces synthetic, proinflammatory phenotypes in cultured human intestinal smooth muscle, with the potential to alter signaling to adjacent bowel cells

SWANS: A highly configurable analysis pipeline for single-cell and single-nuclei RNA-sequencing data

SWANS is a configurable scRNA-seq analysis pipeline that integrates multiple methods and generates interactive reports for data visualization and comparison.

Diverticular disease genome-wide association meta-analysis identifies 257 novel loci, implicates structure and motility

This study identifies 257 novel genetic loci associated with diverticular disease through a large GWAS, linking them to connective tissue and colonic motility mechanisms.

Dietary manipulation of intestinal microbes prolongs survival in a mouse model of Hirschsprung disease

This study shows that diet can significantly affect survival in a mouse model of Hirschsprung disease by altering gut microbes, metabolites, and epithelial gene expression.

Bowel dysmotility and enteric neuron degeneration in lysosomal storage disease mice is prevented by gene therapy

This paper shows gene therapy prevents bowel motility issues and enteric neuron loss in mouse models of lysosomal storage diseases.