Author

Frauke Devens

German Cancer Research Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Aurélie ErnstiD· 2 shared Agata Rode· 1 shared Alexandra Eliassaf· 1 shared Anna Sophia JauchiD· 1 shared Batsheva KeremiD· 1 shared Daniel HaagiD· 1 shared George PhilipposiD· 1 shared Gianluca SigismondoiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Aurélie ErnstORCID

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2 papers

Recent·Most cited

P53 deficiency triggers hypertranscription, inducing nucleotide insufficiency causing replication stress, and genomic instability

Wisam Zaatra, George Philippos, Petr Smirnov, Shira Milo, Jan Otoničar, Michelle Chan, Michal Harel, Frauke Devens, Tchelet Goldberg, Alexandra Eliassaf, Karen Grimes, Michal Irony‐Tur Sinai, Gianluca Sigismondo, Tamar Geiger, Jan O. Korbel, , Aurélie Ernst

This study shows that p53 deficiency causes hypertranscription and nucleotide insufficiency, leading to replication stress and genomic instability, including chromothripsis.

bioRxiv · Apr 17, 2025 · PreprintCancer Biology

A versatile system to introduce clusters of genomic double-strand breaks in large cell populations

Thorsten Kolb, Umar Khalid, Milena Simovic-Lorenz, Manasi Ratnaparkhe, John Wong, Anna Sophia Jauch, Peter Schmezer, Agata Rode, Shulamit Sebban, Daniel Haag, Michaela Hergt, Frauke Devens, Yosef Buganim, Marc Zapatka, Peter Lichter, Aurélie Ernst

This paper introduces a method to generate localized DNA double-strand breaks in cell populations using UV-irradiation with photomasks, enabling the study of genome rearrangements and DNA damage response.

Genes Chromosomes and Cancer · Jul 31, 2020Peer-reviewedGenomics