Author

Luis Enrique Arroyo‐García

Karolinska InstitutetORCID 0000-0002-9206-0179Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Adamantia F. FragopoulouiD· 2 shared André FisahniD· 2 shared Efthalia Preka· 2 shared Giusy PizzirussoiD· 2 shared Klas BlomgreniD· 2 shared Patricia Rodriguez‐RodrigueziD· 2 shared Ahmed M. OsmaniD· 1 shared Aiden Peter CorviniD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Adamantia F. FragopoulouORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A schizophrenia-associated radial glia cell state perturbs early human brain development

Susmita Malwade, Samudyata Samudyata, Jessica Gracias Lekander, Angelika Langeder, Katharina Weinberger, Marja Koskuvi, Ana Osório Oliveira, Šárka Lehtonen, Luis Enrique Arroyo‐García, Aiden Peter Corvin, Sarah E. Bergen, Ilkka Ojansuu, Olli Vaurio, Jari Koıstınaho, Jari Tiihonen, Carl M. Sellgren

This study identifies a schizophrenia-associated radial glia cell state that disrupts early human brain development through single-cell transcriptomic and epigenomic analyses of organoids.

bioRxiv · Oct 24, 2025 · PreprintNeuroscience

Microglia Adopt Temporally Specific States after Irradiation, Correlating with Neuronal Asynchrony

Alejandro Lastra Romero, Efthalia Preka, Giusy Pizzirusso, Luis Enrique Arroyo‐García, Georgios Alkis Zisiadis, Nuria Oliva‐Vilarnau, Yana Ruchiy, Thea Seitz, Kai Zhou, Arturo G. Isla, Lara Frieß, Ying Sun, Maria Querol Canut, Alia Shamikh, Yiran Xu, , Klas Blomgren

This study tracks microglial state changes and neuronal asynchrony after irradiation in mice, showing delayed microglial responses and two phases of neuronal dysfunction.

bioRxiv · Feb 15, 2025 · PreprintNeuroscience

Association of microglia loss with hippocampal network impairments as a turning point in the amyloid pathology progression.

Giusy Pizzirusso, Efthalia Preka, Julen Goikolea, Celia Aguilar-Ruiz, Patricia Rodriguez‐Rodriguez, Guillermo Vazquez Cabrera, Simona Laterza, María Latorre‐Leal, Francesca Eroli, Klas Blomgren, Silvia Maioli, Per Nilsson, Adamantia F. Fragopoulou, André Fisahn, Luis Enrique Arroyo‐García

The paper investigates how microglia loss in the hippocampus contributes to early amyloid pathology progression by disrupting neural oscillations and synaptic function in a mouse model.

bioRxiv · Mar 14, 2024 · PreprintNeuroscience

The proto-oncogene DEK regulates neuronal excitability and tau accumulation in Alzheimer's disease vulnerable neurons

Patricia Rodriguez‐Rodriguez, Luis Enrique Arroyo‐García, Lechuan Li, Christina Tsagkogianni, Wei Wang, Isabella Salas-Allende, Zakary Plautz, Ángel Cedazo-Mı́nguez, Subhash C. Sinha, Olga G. Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussarie

The paper identifies DEK as a driver of tau pathology in Alzheimer's disease vulnerable neurons using in silico modeling and experimental validation.

bioRxiv · May 14, 2022 · PreprintNeuroscience