Marco Fragai

Structural Basis for Human Milk Oligosaccharides Recognition by Evolutionarily Dominant Norovirus Genogroup II Genotypes

This study investigates how different norovirus genotypes recognize human milk oligosaccharides using structural and biochemical methods, revealing genotype-specific binding mechanisms.

Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae

This study isolates human monoclonal antibodies against hypervirulent, pandrug-resistant Klebsiella pneumoniae and identifies capsule-specific antibodies as protective against bloodstream infection.

Deciphering the RNA recognition by Musashi-1 to design protein and RNA mutants for in vitro and in vivo applications

The paper uses structural biology and computational methods to design MSI-1 mutants that alter RNA binding selectivity, validated by NMR and SPR experiments.

HuR modulation with tanshinone mimics impairs LPS response in murine macrophages

This study shows that tanshinone mimics inhibit HuR-RNA interactions, reducing LPS-induced inflammation in macrophages by decreasing cytokine and chemokine expression.