Katharina Eichler

The paper presents the complete connectome of the Drosophila male central nervous system and compares it to the female connectome, identifying sex-specific and dimorphic neuronal types.

The paper presents the first densely reconstructed adult fruit fly connectome integrating the brain and ventral nerve cord, revealing distributed control circuits involving local and long-range neural connections.

The paper identifies distinct octopaminergic neuron populations in Drosophila that drive arousal in larvae and adults, revealing a developmental switch in sleep-wake circuit architecture.

The paper identifies and analyzes sexually dimorphic neurons in the Drosophila brain using connectome data to understand their connectivity and functional roles in behavior.

The paper updates a catalogue of split-GAL4 driver lines for descending neurons in Drosophila melanogaster by adding new cell types and driver lines.

The paper presents the first neuronal wiring diagram of a whole adult Drosophila brain, revealing synaptic connections and circuit mechanisms underlying sensorimotor behaviors.

The paper creates a computational model of the Drosophila brain connectome to study sensorimotor processing and validates predictions through experiments.

This study identifies two distinct neural mechanisms for context-specific halting in Drosophila during feeding and grooming behaviors.

The paper analyzes the network properties of the Drosophila whole-brain connectome, identifying rich club organization and signal integration/broadcasting neurons.

The paper provides a connectomic description of ascending and descending neurons in the Drosophila nervous system, revealing sexual dimorphism and motor-related circuits.

The paper uses artificial neural networks to classify neurotransmitters from electron microscopy images of Drosophila melanogaster synapses, achieving high accuracy and revealing ultrastructural differences.

The paper introduces a method to learn a causal model of the fly brain using a connectome and optogenetic perturbation data, revealing that global brain dynamics arise from small, localized circuits.

The paper investigates the role of the APL neuron in larval Drosophila, finding that optogenetic activation can induce a rewarding effect through dopaminergic pathways.

Annotating the 127,978-neuron FlyWire fly connectome yields 4,552 cell types, 3,094 cross-validated against the hemibrain; cell-type edges above 10 synapses or 1.1% of input recur over 90% across hemispheres.

1328 descending and 733 motor neurons of the male Drosophila nerve cord connectome were curated; direct links between them are infrequent, and intrinsic-neuron communities route control per motor system.

Roughly 23 thousand traced neurons and 10 million TBars of the male Drosophila nerve cord, reconstructed from electron microscopy, typed, and queryable in neuPrint down to motor neurons.

The paper systematically annotates a complete adult male Drosophila nerve cord connectome, identifying neuron types, connectivity patterns, and sensory modalities to reveal organizational principles.

The paper identifies mechanosensory neurons in Drosophila that elicit specific head grooming behaviors and maps their synaptic projections to define parallel pathways involved in grooming sequences.

The paper maps convergence neurons in Drosophila that integrate innate and learned olfactory drives to mediate action selection.

The paper identifies distinct mechanosensory neuron subpopulations in Drosophila that converge onto a shared neural circuit to elicit grooming behavior.

The paper maps the synaptic connectome of the Drosophila larva mushroom body and identifies feedback pathways that enable modulatory neurons to compute teaching signals for reinforcement learning.

The paper reconstructs the complete synaptic connectome of the Drosophila larval mushroom body, revealing novel circuit structures and input integration patterns in Kenyon cells.