Author

Tobias Nespital

Max Planck Institute for Biology of AgeingORCID 0000-0002-8451-2331Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Linda PartridgeiD· 2 shared Maarouf BaghdadiiD· 2 shared Sebastian GrönkeiD· 2 shared Andrea MesarosiD· 1 shared Andreas BeyeriD· 1 shared Anna Lena Cremer· 1 shared Carolina MonzóiD· 1 shared Dominic J. WithersiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersPhysiology

Linda PartridgeORCID

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2 papers

Recent·Most cited

A combination of the geroprotectors trametinib and rapamycin is more effective than either drug alone

Lisonia Gkioni, Tobias Nespital, Maarouf Baghdadi, Carolina Monzó, Jitin Bali, Taim Nassr, Anna Lena Cremer, Andreas Beyer, Joris Deelen, Heiko Backes, Sebastian Grönke, Linda Partridge

This study shows that combining trametinib and rapamycin extends mouse lifespan more than either drug alone and improves health markers in older age.

Nature Aging · May 28, 2025Peer-reviewedPhysiology

Reduced insulin signalling in neurons induces sex-specific health benefits

Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J. Withers, Sebastian Grönke, Linda Partridge

This study identifies male-specific brain aging improvements from reduced neuronal insulin signaling in mice.

bioRxiv · Sep 19, 2022 · PreprintNeuroscience