Maxime De Waegeneer

Developmental transcriptional control of mitochondrial homeostasis is required for activity-dependent synaptic connectivity

The paper identifies TZAP as a developmental regulator of mitochondrial homeostasis critical for activity-dependent synaptic connectivity in Drosophila.

Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

Decoding gene regulation in the fly brain

The paper identifies regulatory regions and gene regulatory networks in Drosophila brain cell types using chromatin accessibility and transcriptome data.

Analysis of long and short enhancers in melanoma cell states

The paper identifies and characterizes enhancer activity in melanoma cell states using MPRA and DeepMEL2, showing AP-1 drives MES enhancers and SOX/MITF influence MEL enhancers.

Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics

The paper spatially integrates single-cell transcriptomics and epigenomics data to identify enhancers and gene regulatory relationships in Drosophila eye-antennal disc.

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switching

The paper identifies an intermediate cell state in melanoma through single-cell RNA-seq and ATAC-seq, revealing a gene regulatory network that governs phenotype switching and potential therapeutic targets.

A single-cell catalogue of regulatory states in the ageing Drosophila brain

This study creates a single-cell transcriptome catalogue of the Drosophila brain across its lifespan, revealing regulatory erosion and identifying novel neuronal states linked to ageing.