Tsui-Wen Chou

Intestinal uptake regulates T cell responses to dietary antigens

Intestinal uptake, set by protein solubility and goblet versus M cell sampling, limits how strongly different zein preparations induce antigen-specific intestinal T cells in mice.

Astrocytic RIPK3 exerts protective anti-inflammatory activity during viral encephalitis via induction of serpin protease inhibitors.

This study shows that astrocytic RIPK3 reduces inflammation in viral encephalitis by increasing serpin protease inhibitors, improving survival and BBB integrity.

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

This study shows that neuronal DAMPs activate astrocytic RIPK3 signaling, leading to neuroinflammation and dopaminergic cell death in Parkinson's disease.

RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection

This study identifies RIPK3's role in promoting neuronal survival during CNS viral infection by suppressing excitatory neurotransmission, independent of its traditional necroptotic function.

Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders

This study shows ZIKV infection alters neurologic gene expression linked to psychiatric disorders through TNF-α signaling in neurons and mouse models.

Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

This study shows that α-synuclein fibrils activate midbrain astrocytes through RIP kinase and NF-κB signaling, leading to neurotoxicity and inflammation in Parkinson's disease.