Jiannis Ragoussis

The paper uses single-nucleus RNA sequencing to identify gene expression changes in specific cell types associated with major depressive disorder.

The paper assembles the olive fruit fly genome using linked-reads and long-read technologies, achieving a highly contiguous Y-chromosome assembly.

The paper identifies a Y-linked gene, MoY, essential for male sex determination in medflies and shows its conservation across multiple fruit fly species, enabling potential genetic control strategies.

The paper uses single-cell RNA-seq to show glioblastoma recapitulates normal brain development, identifying a conserved trilineage hierarchy with glial progenitor-like cells as the origin of cancer heterogeneity and therapeutic targets.

The paper evaluates a custom 13-gene breast cancer panel for variant calling, showing high target capture efficiency and concordance with validated variants.

This study benchmarks the Oxford Nanopore MinION sequencing platform for quantifying and assessing the quality of cDNA populations using synthetic and complex samples.