Yu Chang Wang

Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis pathophysiology

This study investigates ependymal cilia dysfunction in multiple sclerosis, finding dysregulated ciliary genes and impaired ciliary function in MS patients and animal models.

Inhibition of Type I PRMTs Reforms Muscle Stem Cell Identity Enhancing their Therapeutic Capacity

This study shows that inhibiting type I PRMTs with MS023 enhances muscle stem cell proliferation and regenerative potential while maintaining stemness.

Improved Nanopore full-length cDNA sequencing by PCR-suppression

The paper introduces a new Nanopore cDNA library preparation protocol that improves PCR efficiency and gene body coverage for full-length transcript sequencing.

Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis

The paper identifies two distinct epithelial cell lineages in the oviduct, spatially separated along the distal-proximal axis, with distinct developmental origins.

Transcriptome landscape of the developing olive fruit fly embryo delineated by Oxford Nanopore long-read RNA-Seq

This study uses Oxford Nanopore long-read RNA-Seq to characterize the transcriptome of the olive fruit fly embryo during early development, revealing novel genes and transcriptional dynamics.

Single-nucleus RNA sequencing shows convergent evidence from different cell types for altered synaptic plasticity in major depressive disorder.

The paper uses single-nucleus RNA sequencing to identify gene expression changes in specific cell types associated with major depressive disorder.

Benchmarking of the Oxford Nanopore MinION sequencing for quantitative and qualitative assessment of cDNA populations

This study benchmarks the Oxford Nanopore MinION sequencing platform for quantifying and assessing the quality of cDNA populations using synthetic and complex samples.