Kevin Petrecca

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

An integrative layer-resolved atlas of the adult human meninges

This study creates the first layer-resolved atlas of the adult human meninges using single-cell RNA sequencing, MERFISH, and immunolabeling, identifying 10 fibroblast subpopulations and novel interactions in the dura and subarachnoid space.

Somatic instability of the FGF14-SCA27B GAA·TTC repeat reveals a marked expansion bias in the cerebellum

This study examines somatic instability of the FGF14 GAA·TTC repeat in SCA27B, finding a cerebellar-specific expansion bias and increased instability in cerebellar regions compared to other brain areas.

Identity and Nature of Neural Stem Cells in the Adult Human Subventricular Zone

This study creates a cell atlas of the adult human subventricular zone using single-cell transcriptomics, identifying multipotent neural stem cells and their lineage potential.

Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain development

The paper uses single-cell RNA-seq to show glioblastoma recapitulates normal brain development, identifying a conserved trilineage hierarchy with glial progenitor-like cells as the origin of cancer heterogeneity and therapeutic targets.