Author

Spyridon Oikonomopoulos

McGill Genome Centre

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Jiannis RagoussisiD· 4 shared David L. GibbsiD· 2 shared Deng Pan· 2 shared Haig Hugo Vrej DjambazianiD· 2 shared Joseph A. CarusoiD· 2 shared Julie Bérubé· 2 shared Lorenzo Edwin FerriiD· 2 shared Nicholas BertosiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Jiannis RagoussisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

Ariel Madrigal, Minjun Kim, Zohreh Mehrjoo, Tamiko Nishimura, Özge Saatci, Adrien Osakwe, Evelyn Zavacky, Elham Moslemi, Kate I. Glennon, Matthew Dankner, Sarah M. Maritan, Hellen Kuasne, Virginie Pilon, Anie Monast, Mustafa Soytaş, , Hamed Shateri Najafabadi

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

medRxiv · Jul 16, 2026 · PreprintGenetic & Genomic Medicine

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

Shoval Miyara, Shachaf Frenkel, Avi Mayo, Philippe D. Gascard, Michael Strasser, David L. Gibbs, Eviatar Weizman, Isaac Shalom, Yaniv Stein, Deng Pan, Joseph A. Caruso, Veena Sangwan, Nicholas Bertos, Julie Bérubé, Sophie Camilleri‐Broët, , Uri Alon

The paper identifies a cold fibrotic network in LUSC TME driven by CAFs and shows its conservation in other CIACs, suggesting therapeutic targets.

bioRxiv · Aug 25, 2025 · PreprintCancer Biology

A Fibroblast State Choreographs an Epithelial YAP-dependent Regenerative Program Essential to (Pre)malignancy via ECM-mediated Mechanotransduction

Deng Pan, Philippe D. Gascard, Joseph A. Caruso, Chira Chen‐Tanyolac, Veena Sangwan, Nicholas Bertos, Sophie Camilleri‐Broët, Julie Bérubé, Spyridon Oikonomopoulos, Michael K. Strasser, David L. Gibbs, Joanna Bons, Jordan B. Burton, Jacob Rose, Samah Shah, , Thea Dorothy Tlsty

The paper identifies a fibroblast state called STIF that drives YAP-dependent regenerative programs and (pre)malignancy through mechanotransduction in response to tissue injury.

bioRxiv · Jul 11, 2025 · PreprintCancer Biology

De novo genome assembly of the olive fruit fly (Bactrocera oleae) developed through a combination of linked-reads and long-read technologies

Anthony Bayega, Haig Hugo Vrej Djambazian, Konstantina T. Tsoumani, Maria‐Eleni Gregoriou, Efthimia Sagri, Elena Drosopoulou, Penelope Mavragani‐Tsipidou, Kristina Giorda, George Tsiamis, Kostas Bourtzis, Spyridon Oikonomopoulos, Ken Dewar, Deanna M. Church, Alexie Papanicolaou, Kostas D. Mathiopoulos, Jiannis Ragoussis

The paper assembles the olive fruit fly genome using linked-reads and long-read technologies, achieving a highly contiguous Y-chromosome assembly.

BMC Genomics · Mar 30, 2020Peer-reviewedGenomics