Irena Rektorová

A 'brain-first' mouse model of progressive alpha-synuclein pathology via intranasal rotenone administration

This study develops a mouse model of Parkinson's disease by intranasal rotenone administration, showing progressive alpha-synuclein pathology from the olfactory bulb to other brain regions.

EEG dynamics in Lewy body diseases is related to clinical fluctuations and degeneration of locus coeruleus

This study examines neuronal avalanches in Lewy body diseases, finding increased brain dynamics flexibility linked to clinical symptoms and degeneration of the locus coeruleus.

Genomic analyses reveal new insights into Alzheimer's disease

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinsons disease

The paper identifies PPM1M as a phosphatase that reverses LRRK2-mediated Rab phosphorylation and links a rare mutation to Parkinson's disease.

Small effect size leads to reproducibility failure in resting-state fMRI studies

This paper shows that small effect sizes in resting-state fMRI studies lead to reproducibility issues, even after multiple comparison corrections, and recommends meta-analysis of un-thresholded data for better results.