Author

Pimchai Chaiyen

Vidyasirimedhi Institute of Science and TechnologyORCID 0000-0002-8533-1604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Chalermroj SutthaphiromiD· 2 shared Andrea SchenkmayerováiD· 1 shared Andrew J. deMelloiD· 1 shared Chatchai KesornpuniD· 1 shared David BednářiD· 1 shared Edda KlippiD· 1 shared Emirhan Cenk Ulas· 1 shared Frank HollmanniD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Chalermroj SutthaphiromORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Conformational gating of product release sets the catalytic ceiling of a bioluminescent reporter

Martin Toul, Jana Horáčková, Andrea Schenkmayerová, Joan Planas-Iglesias, Tomas Landolt, Jeerus Sucharitakul, Yves Louis Janin, Kridsadakorn Prakinee, Pimchai Chaiyen, Stavros Stavrakis, Andrew J. deMello, Kenneth Allen Johnson, Jiřı́ Damborský, Martin Marek, David Bednář, Zbyněk Prokop

This study identifies conformational dynamics as a key determinant of luciferase catalytic efficiency and light-emission stability, revealing a trade-off between oxygen affinity and enzyme longevity.

bioRxiv · Sep 16, 2025 · PreprintBiochemistry

Thermodynamically Explicit Kinetics with Potential for Genome-wide Application

Oliver Bodeit, Chalermroj Sutthaphirom, Emirhan Cenk Ulas, Rune Linding, Pimchai Chaiyen, Edda Klipp

This paper introduces a Thermodynamically Explicit kinetic framework for dynamic metabolic modeling, validated on glycolysis, offering a scalable tool for genome-wide applications.

bioRxiv · Mar 2, 2025 · PreprintBiophysics

A versatile in situ cofactor enhancing system for meeting cellular demands for engineered metabolic pathways

Juthamas Jaroensuk, Chalermroj Sutthaphirom, Jittima Phonbuppha, Wachirawit Chinantuya, Chatchai Kesornpun, Nattanon Akeratchatapan, Narongyot Kittipanukul, Kamonwan Phatinuwat, Sopapan Atichartpongkul, Mayuree Fuangthong, Thunyarat Pongtharangkul, Frank Hollmann, Pimchai Chaiyen

This paper demonstrates that increasing sugar phosphates using the XR/lactose system enhances cofactor generation in engineered metabolic pathways in E. coli, improving productivities by 2-4-fold.

bioRxiv · Jan 8, 2023 · PreprintSynthetic Biology