Cooperativity between H3.3K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatars
Kasey Skinner, Tomoyuki Koga, Shunichiro Miki, Robert F. Gruener, Florina Grigore, Emma H. Torii, Davis M. Seelig, Yuta Suzuki, Daisuke Kawauchi, Benjamin Lin, Denise M. Malicki, Clark C. Chen, Etty N. Benveniste, Rakesh P. Patel, Braden C. McFarland, , Frank B. Furnari
This study develops human iPSC-derived tumor models to investigate the cooperative effects of H3.3K27M and PDGFRA mutations in DMG, identifying therapeutic vulnerabilities.
bioRxiv · Feb 24, 2023 · PreprintGenomics