Frank B. Furnari

This study uses single-molecule spatial genomics to show how extrachromosomal DNA is organized and regulated in glioblastoma, linking it to tumor heterogeneity and microenvironmental influences.

The paper introduces Droplet Hi-C, a method for single-cell chromatin conformation profiling, and demonstrates its application in analyzing gene regulatory programs and detecting genetic variations in cancer cells.

This study develops human iPSC-derived tumor models to investigate the cooperative effects of H3.3K27M and PDGFRA mutations in DMG, identifying therapeutic vulnerabilities.

This study investigates the role of Pten T366 phosphorylation in cortical connectivity and behavior, finding that its disruption leads to cognitive deficits and sensory impairments in mice.