Author

Kaeli M. Mathias

Children's Hospital of PhiladelphiaORCID 0000-0002-8577-9193Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Charles Antony AiD· 1 shared Chujie GongiD· 1 shared Eric F. JoyceiD· 1 shared Frédéric LessardiD· 1 shared Haitao LiiD· 1 shared Krista A. BudinichiD· 1 shared Lele SongiD· 1 shared Liling WaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Charles Antony AORCID

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2 papers

Recent·Most cited

Lineage-specific transcription factor CEBPA accelerates RNA Polymerase I dynamics

Charles Antony A, Santosh Adhikari, Subin S. George, Taejun Son, Kaeli M. Mathias, Frédéric Lessard, Tom Moss, Mustafa Mir, Vikram R. Paralkar

This study shows that the myeloid transcription factor CEBPA accelerates RNA Polymerase I dynamics at rDNA repeats by modulating promoter escape, Pol I accumulation, and DNA supercoiling resolution.

bioRxiv · Oct 27, 2026 · PreprintMolecular Biology

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

Krista A. Budinich, Xinyi Yao, Chujie Gong, Lele Song, Xiaoting Wang, Michelle C. Lee, Kaeli M. Mathias, Qinglan Li, Sylvia Tang, Yiman Liu, Son C. Nguyen, Eric F. Joyce, Yuanyuan Li, Haitao Li, Liling Wan

The paper shows that RNA enhances condensate formation by ENL mutants, promoting oncogenic transcription and leukemogenesis in mouse models.

Molecular Cell · Jun 12, 2026Peer-reviewedMolecular Biology