Philip D. Hodgkin

Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease

The paper uses a novel assay and mathematical model to show CD4+ T cells from celiac disease patients have reduced proliferation and altered cytokine secretion compared to healthy donors.

Genome reorganization prior to mitosis shapes the generation of adaptive immunity

The paper shows genome reorganization occurs in discrete waves before DNA replication and mitosis, controlling B cell differentiation into plasma cells.

SIS-seq, a molecular ‘time machine’, connects single cell fate with gene programs

SIS-seq links gene expression with cell fate by analyzing clonal progeny, identifying early gene signatures of dendritic cell subset development.

Assessment of clonal kinetics reveals multiple trajectories of dendritic cell development

The paper assesses clonal kinetics in dendritic cell development and identifies multiple distinct trajectories with intrinsic programming.