Vanessa L. Bryant

Single-cell CRISPR activation screens in primary B cells discover gene regulatory mechanisms for hundreds of autoimmune risk loci.

The paper uses single-cell CRISPR activation screens in human B cells to link non-coding autoimmune risk loci to their cis-regulatory target genes, revealing shared genetic mechanisms across diseases.

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

The paper identifies transcriptional modules and cytokine signaling pathways that drive functional heterogeneity in T follicular helper cells across different infections.

Functional immune profiling reveals CD4+ T cell dysregulation associated with celiac disease

The paper uses a novel assay and mathematical model to show CD4+ T cells from celiac disease patients have reduced proliferation and altered cytokine secretion compared to healthy donors.

A Risk-reward Examination of Sample Multiplexing Reagents for Single Cell RNA-Seq

This study evaluates sample multiplexing reagents and protocols for scRNA-Seq, finding that workflow improvements and reagent choice impact data quality and cost-effectiveness.

MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays

MaveDB v2 curates over three million variant effects from MAVE studies to facilitate analysis and dissemination of functional assay data.