Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate
Andrew Orenberg, Michael J. Chirumbolo, Ian Eder, Jia-Jun Liu, Silvia Liu, David M. Gau, Yubo Tang, Klemens Rottner, Jianhua Luo, Gerald R. V. Hammond, Partha Roy
This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.
Journal of Cell Science · May 21, 2026Peer-reviewedCell Biology