Author

Jianhua Luo

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Ian EderiD· 2 shared Partha Sarathi RoyiD· 2 shared Silvia LiuiD· 2 shared Abrahim Kashkoush· 1 shared Andrew OrenbergiD· 1 shared David M. GauiD· 1 shared Elijah Wilson· 1 shared Gerald R. V. HammondiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Ian EderORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast Cancer

Ian Eder, Masoumeh Baghaei, Sudeep K. Maurya, Virginia Yu, Elijah Wilson, Abrahim Kashkoush, Jia-Jin Liu, Silvia Liu, Jianhua Luo, Walter J. Storkus, Partha Sarathi Roy

This paper shows that reducing Profilin-1 in breast cancer cells triggers genomic instability and activates the cGAS-STING pathway, enhancing T cell-mediated anti-tumor immunity and leading to tumor regression.

bioRxiv · Jun 10, 2026 · PreprintCancer Biology

Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate

Andrew Orenberg, Michael J. Chirumbolo, Ian Eder, Jia-Jun Liu, Silvia Liu, David M. Gau, Yubo Tang, Klemens Rottner, Jianhua Luo, Gerald R. V. Hammond, Partha Roy

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

Journal of Cell Science · May 21, 2026Peer-reviewedCell Biology