Partha Sarathi Roy

Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast Cancer

This paper shows that reducing Profilin-1 in breast cancer cells triggers genomic instability and activates the cGAS-STING pathway, enhancing T cell-mediated anti-tumor immunity and leading to tumor regression.

Molecular insights into Profilin1-dependent regulation of cellular phosphatidylinositol-(4,5)-bisphosphate

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

Small molecule intervention of actin-binding protein profilin1 reduces tumor angiogenesis in renal cell carcinoma

This study shows that a small molecule Pfn1 inhibitor reduces tumor angiogenesis in renal cell carcinoma by targeting endothelial cell Pfn1.

Hope for Others: Research Results from the University of Pittsburgh Rapid Autopsy Program for Breast Cancer

The paper describes the Hope for Others rapid autopsy program for metastatic breast cancer, detailing its protocols, sample collection, and findings on metastasis research and model development.

Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer.

This study identifies the MRTFA/SRF pathway as a regulator of quiescence in cancer and shows that inhibiting it induces quiescence and reduces tumor growth.