Klemens Rottner

The paper identifies Y16 phosphorylation as a conserved switch controlling Ena/VASP recruitment to actin assembly sites, using cell-based reconstitution and biochemical assays.

This study shows that Arp2/3 complex-dependent actin remodeling is necessary for efficient RSV uncoating in A549 cells, as Arp2 knockout cells exhibit reduced infection and viral mRNA expression.

This study shows that loss of Profilin1 reduces plasma membrane PIP2 levels, linking actin regulation to PIP2 homeostasis and revealing Pfn1's broader role in lipid metabolism.

This study shows Asgard archaea use dynamic actin-based protrusions for crawling motility, similar to eukaryotic cells, and this process is inhibited by actin inhibitors.

This study shows cytochalasin B differentially affects barbed end-binding proteins in lamellipodia, enhancing rather than inhibiting their accumulation and interactions.

This study investigates how profilin regulates lamellipodium protrusion by modulating the interactions between the Arp2/3 complex, capping protein, and Ena/VASP proteins.

This study identifies cortactin as an interactor of dystrobrevin-1, showing its role in neuromuscular junction morphology but not muscle strength.