Author

Sarah M. C. Nicoloro

University of Massachusetts Chan Medical SchoolORCID 0000-0002-8638-4556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Hui WangiD· 3 shared Lawrence M. LifshitziD· 3 shared Michael CzechiD· 3 shared Adı́lson GuilhermeiD· 2 shared Kaltinaitis B. SantosiD· 2 shared Leslie A. RowlandiD· 2 shared Mark KellyiD· 2 shared Alvin Yu Jin NgiD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersPhysiology

Hui WangORCID

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3 papers

Recent·Most cited

Thermogenic adipocytes alleviate hepatic steatosis and insulin resistance via macrophage cytokine secretion in obese mice

Hui Wang, Mark Kelly, Najihah Aziz, Emmanouela Tsagkaraki, Sarah M. C. Nicoloro, Lawrence M. Lifshitz, Adı́lson Guilherme, Leslie A. Rowland, Batuhan Yenilmez, Kaltinaitis B. Santos, Naideline Raymond, Tiffany DeSouza, Muhammad Tanveer Sajid, Hanna Choi, LAUREN A. TAUER, , Michael Czech

This study shows that adipocyte Nrip1 deficiency in obese mice reduces hepatic steatosis and insulin resistance by promoting M2-like macrophages that secrete IL-1rn.

bioRxiv · Aug 1, 2025 · PreprintPhysiology

A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes

Franziska Paul, Hui Wang, Jianqin Wang, Liang Juin Tan, Crystal Y. Chia, Li Sun, Hui Jen Goh, Mark Kelly, Suresh Anand Sadananthan, Gunaseelan Narayanan, Lawrence M. Lifshitz, S. Sendhil Velan, Sarah M. C. Nicoloro, Sumanty Tohari, Alvin Yu Jin Ng, , Bruno Reversade

This study identifies a dominant CIDEC variant causing familial obesity by increasing lipid droplet size in adipocytes through structural and functional changes.

medRxiv · Jul 28, 2025 · PreprintGenetic & Genomic Medicine

The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue

Leslie A. Rowland, Kaltinaitis B. Santos, Adı́lson Guilherme, Sean Munroe, Lawrence M. Lifshitz, Sarah M. C. Nicoloro, Hui Wang, Matthew F. Yee, Michael Czech

This study identifies Ncoa4 as a regulator of PPARγ activity and thermogenesis in brown adipose tissue through genetic and functional analyses.

bioRxiv · Feb 2, 2025 · PreprintMolecular Biology