Author

Prachi N. Ghule

University of VermontORCID 0000-0002-8640-5070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Gary S. SteiniD· 2 shared Seth E. FrietzeiD· 2 shared Abigail G. Person· 1 shared Alquassem Abuorquob· 1 shared Alyssa R. RichmaniD· 1 shared Amrita PalariaiD· 1 shared André J. van WijneniD· 1 shared Andrew J. FritziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Gary S. SteinORCID

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2 papers

Recent·Most cited

Acute degron-mediated RUNX1 loss reprograms enhancer activity to epigenetically drive epithelial destabilization and initiate cancer hallmarks

Andrew J. Fritz, Haley W. Greenyer, Louis Dillac, Priyanka Chavarkar, Rahim Ullah, Miles Malik, Deli Hong, Rabail Hassan Toor, Emory Pacht, Abigail G. Person, Georgiy Zotkin, Sadie J Korzec, Cong Gao, Alquassem Abuorquob, Janine S. A. Warren, , Gary S. Stein

This study shows that acute RUNX1 loss reprograms enhancer activity, leading to epithelial destabilization and cancer hallmark activation in human mammary epithelial cells.

bioRxiv · Mar 28, 2026 · PreprintCancer Biology

IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic Leukemia

Hana Paculová, Alyssa R. Richman, Joseph Boyd, Joshua Carlos Bernil, Princess Rodriguez, Etapong Fonabei Ayongaba, Prachi N. Ghule, Elsa Drivet, Amrita Palaria, Mariam Dajani, Els Verhoeyen, Anthony J. Saviola, Gary S. Stein, Hilde Schjerven, Seth E. Frietze

This study identifies ERG as a vulnerability in IKZF1-mutated B-cell acute lymphoblastic leukemia through gene regulatory network analysis and functional validation.

bioRxiv · Dec 29, 2025 · PreprintCancer Biology